White Matter Abnormalities and Animal Models Examining a Putative Role of Altered White Matter in Schizophrenia

Figure 1

Effects of antipsychotics on the CPZ-induced deficits in PPI test. Control and experimentally treated C57BL/6 mice were subjected to PPI test on the same day (14th day after CPZ exposure). (a) The data of the HAL experiment. (b) The data of the CLZ experiment. (c) The data of the QUE experiment. Data were expressed as M ± SEM (𝑛=6 to 12/group). CNT: control group; CPZ: cuprizone group; CLZ: clozapine group; HAL: haloperidol group; QUE: quetiapine group; CPZ+CLZ: mice received both cuprizone and clozapine; CPZ+HAL: mice received both cuprizone and haloperidol; CPZ+QUE: mice received both cuprizone and quetiapine. PPI: prepulse inhibition; db: decibel. *𝑃<0.05, **𝑃<0.01, compared to the CNT group; ⁺𝑃<0.05, compared to the CPZ group.

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