White Matter Abnormalities and Animal Models Examining a Putative Role of Altered White Matter in Schizophrenia

Table 1

Comparison of animal models examining a putative role of altered white matter in schizophrenia.

	plp1^tg/−  mice	NRG1-erbB4 transgenic mice	Nogo-A deficient mice	CPZ-fed mice
Altered myelin structure	—	√	No data	√
OL loss	No data	√	No data	√
Decreased axonal conductance	√	√	No data	No data
Dopamine level	No data	No data	↓	↑
D2 receptors	No data	↑	↓	No data
NMDA receptors	No data	↓	No data	No data
Hyperactivity	No data	√	No data	√
Anxiety-like behaviors	√	√	√	√
Disrupted PPI	√	√	√	√
Spatial learning deficit	√	√	No data	√
Working memory deficit	√	√	No data	√
Impaired social activities	No data	√	—	√
Response to antipsychotics	No data	√	No data	√