Synthesis and Antibacterial Activity of 3-(Substituted)-2-(4-oxo-2-phenylquinazolin-3(4H)-ylamino)quinazolin-4(3H)-one
Table 1
Antibacterial activity (zone of inhibition) of newly synthesized 3-(substituted)-2-(4-oxo-2-phenylquinazolin-3(4H)-ylamino)quinazolin-4(3H)-ones (9a–9j).
Microorganisms
Test compounds (zone of inhibition 100 µg/mL) in cm
Standard (10 µg/mL)
9a
9b
9c
9d
9e
9f
9g
9h
9i
9j
S. aureus
0.9
0.6
0.8
0.8
0.7
0.9
0.7
1
0.8
0.8
1.9
B. subtilis
1.4
0.6
1
0.7
1.1
1
0.9
1
0.7
0.9
1.0
E. coli
0.8
0.8
0.8
0.7
1
0.8
1
0.8
0.8
1
2.1
P. vulgaris
1.1
0.8
1
0.9
0.9
1
0.8
1.2
0.7
0.8
1.9
K. pneumoniae
0.4
0.8
0.9
0.8
0.8
0.8
0.8
0.7
1
1
2.1
P. aeruginosa
0.7
0.6
0.8
0.7
0.8
0.9
1
0.8
0.9
0.7
2.2
Ciprofloxacin used as a reference standard for other bacteria.
