Gentamicin Induced Nephrotoxicity: The Role of Sex Hormones in Gonadectomized Male and Female Rats

Figure 2

The effect of progesterone (Pro) without or accompanied with estradiol (ES) (0.25, 0.5, or 1 mg/kg) on the serum levels of blood urea nitrogen (BUN), creatinine (Cr), malondialdehyde (MDA), kidney level of MDA, kidney tissue damage score (KTDS), body weight change (ΔBW), kidney weight (KW), and uterus weight (UW) in female groups treated by gentamicin (GM). #, ×, ¤,  and ¥ indicate significant differences from GM, Pro + GM, Pro + ES 0.25 + GM, and Pro + ES 0.5 + GM groups, respectively.