A High-Fat, High-Fructose Diet Induces Antioxidant Imbalance and Increases the Risk and Progression of Nonalcoholic Fatty Liver Disease in Mice

Figure 1

Histopathology of hematoxylin and eosin (H&E) stained mouse livers. The livers were collected 24 hours after the last treatment. Mice were fed a regular diet (a), or a high-fat, high-fructose diet for 2 weeks (b), 4 weeks (c), or 8 weeks (d). The micrographs are shown at a magnification of 400-fold. The solid arrows indicate sinusoidal pathology, the dash arrows indicate fat droplets, and the gray arrow indicates the foci of lobular inflammation in the liver. PV: portal vein.

(a) Regular diet

(b) High-fat-high-fructose diet, 2 weeks

(c) High-fat-high-fructose diet, 4 weeks

(d) High-fat-high-fructose diet, 8 weeks