Review Article
Medicinal Plants as a Drug Alternative Source for the Antigout Therapy in Morocco
Table 1
The gout treatment drugs and their side effects.
| Gout treatment options | Drugs | Effect | Doses (mg/day) | Side effects |
| Xanthine oxidase inhibitors | Allopurinol | Reduces the level of blood uric acid [9] | 50–800 [9] | (i) Digestive disorders | (ii) Hypersensitivity syndrome | (iii) Hepatotoxicity | (iv) Skin reactions [14] | Febuxostat | Reduces the level of blood uric acid [9] | 80–120 [9] | (i) Digestive disorders | (ii) Headache | (iii) Liver problems | (iv) Rash in the skin [9] |
| Uricosuric agents | Probenecid | Inhibition of the uric acid reabsorption [15] | — | (i) Gastrointestinal tract irritation | (ii) Anorexia | (iii) Skin reactions [9] | Benzbromarone | | 100 | (i) Hepatotoxicity [16] | Lesinurad | Inhibition of the uric acid reabsorption [17] | | (i) Gastroesophageal reflux disease | (ii) Headache | (iii) Influenza associated with kidney failure [9] | Losartan/fenofibrate | Lowering urate formation [18] | | |
| Uricases | Rasburicase | The recombinant form of uricases | | (i) Infusion problems [9] | (ii) Antibody formation [19] | (iii) Anaphylaxis [9] |
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