Antimalarial Activity of Extract and Fractions of Sauropus androgynus (L.) Merr.

Table 2

In vivo suppressive activity of ethanolic leaf extract of S. androgynus (4-day suppressive test) against P. berghei-infected mice.

Drug/Extract	Dose (mg/kg/day)	% Parasitaemia		% Suppression	ED50 (mg/kg bw)
		Day 0	Day 4
Na CMC	—	0.92 ± 0.27	7.59 ± 0.97	—	—
Ethanolic leaf extract of S. androgynus	1	2.37 ± 0.64	6.79 ± 0.67	33.73	15.35
	10	1.95 ± 0.46	5.44 ± 0.38	47.67
	100	0.76 ± 0.25	3.41 ± 0.51	60.26
	200	1.02 ± 0.34	3.28 ± 0.86	66.11
DHA-P	20.8 + 166.4	1.83 ± 0.83	0.00 ± 0.00	100.00	—

Data are expressed as mean ± SEM; n = 6; significance relative to the negative control, .