Antimalarial Activity of Extract and Fractions of Sauropus androgynus (L.) Merr.

Table 6

The IC₅₀ values of ethanolic leaf extract of S. androgynus, chloroquine diphosphate, negative control based on the inhibition test of heme detoxification.

Drug/Extract	Concentration (mg/mL)	Concentration of hemozoin (mM)	% Inhibition	IC50 (mg/mL)
DMSO	—	166.13 ± 11.48	—	—
Ethanolic leaf extract of S. androgynus	4	34.28 ± 1.90	79.36 ± 1.14	0.479
	2	50.29 ± 2.50	69.73 ± 1.50
	1	67.59 ± 5.81	59.31 ± 3.50
	0.5	81.57 ± 2.98	50.90 ± 1.80
	0.25	95.31 ± 2.68	42.63 ± 1.62
	0.1	121.48 ± 3.66	26.87 ± 2.20
Chloroquine diphosphate	4	44.80 ± 3.10	73.04 ± 1.87	0.569
	2	56.42 ± 2.60	66.04 ± 1.56
	1	69.82 ± 4.23	57.97 ± 2.55
	0.5	84.69 ± 2.25	49.02 ± 1.35
	0.25	102.66 ± 3.09	38.21 ± 1.86
	0.1	118.17 ± 4.31	28.87 ± 2.60