Topical Administration Effect of Sargassum duplicatum and Garcinia mangostana Extracts Combination on Open Wound Healing Process in Diabetic Mice
Table 1
Wound healing parameters on day 3, 7, and 14 of treatment.
Groups
Wound width (μm)
Neutrophils (cells/nm2)
Macrophage (cells/nm2)
Fibroblast (cells/nm2)
Fibrocyte (cells/nm2)
Collagen density (%)
KN
Day
3
4849 ± 106.07
117.5 ± 5.42
12.5 ± 1.18
46.17 ± 7.78
21.33 ± 1.41
63.5 ± 4.01
Day
7
1166.17 ± 20.03
88.17 ± 1.18
8.83 ± 0.24
73.67 ± 3.3
28.5 ± 1.65
80.83 ± 1.18
Day
14
206.83 ± 7.78
31.5 ± 0.71
4.67 ± 0.47
45.83 ± 0.24
16.83 ± 1.18
93 ± 1.41
KD
Day
3
2642.17 ± 33.71
159.83 ± 6.36
17 ± 0.94
41.67 ± 10.84
13.17 ± 0.71
56.67 ± 1.89
Day
7
6478.5 ± 320.32
132.67 ± 7.07
15.83 ± 4.01
51.83 ± 9.19
19.5 ± 0.71
60.83 ± 4.01
Day
14
243.17 ± 10.61
57.83 ± 6.84
2.67 ± 0.47
38.83 ± 4.95
14 ± 0.94
89.67 ± 1.41
PA
Day
3
3374.5 ± 381.6
115.5 ± 7.31
11 ± 0.94
35.33 ± 1.89
17 ± 0.94
66.67 ± 0.94
Day
7
1565 ± 447.83
98.5 ± 8.72
9.17 ± 0.71
60.17 ± 3.54
26.67 ± 0.47
87.5 ± 1.18
Day
14
162.33 ± 17.91
61.17 ± 24.75
2.17 ± 0.24
41.83 ± 1.18
14.5 ± 0.24
90.5 ± 0.71
PAM
Day
3
4701.67 ± 68.35
131.67 ± 9.43+
11.83 ± 0.71
35.17 ± 4.01
21.83 ± 0.71
68.83 ± 0,71
Day
7
1512.83 ± 27.11
114.83 ± 9.66
8.67 ± 0.47
67.83 ± 0.71
30.5 ± 1.18
82.17 ± 2.59
Day
14
136.5 ± 4.01
48.17 ± 0.24
1.83 ± 0.24
56 ± 7.07+
17.33 ± 1.41
93.83 ± 2.12
Note: The data are expressed as the mean ± SD (n = 6). compared to the normal control group. compared to the diabetic control group. KN: normal control, KD: diabetic control, PA: S. duplicatum extract treatment, and PAM: combination of S. duplicatum and G. mangostana extracts treatments.
