Acute Ischaemic Stroke in Patients Treated with Direct Oral Anticoagulants: Potential Causes, Clinical Characteristics, and Short-Term Outcomes
Table 2
Comparison of patients with and without prestroke DOAC treatment.
DOAC (+)
DOAC (-)
Risk factors
Age, years (median (IQR))
77 ()
71 ()
<0.001
Female sex ( (%))
66 (60.6%)
310 (47.0%)
0.010
Arterial hypertension ( (%))
95 (87.2%)
474 (71.9%)
<0.001
Diabetes/prediabetes ( (%))
81 (74.3%)
509 (77.2%)
0.540
Dyslipidaemia ( (%))
48 (44.0%)
133 (20.2%)
<0.001
Significant carotid stenosis ( (%))1
19 (19.4%)
144 (24.5%)
0.306
Atrial fibrillation ( (%))
102 (93.6%)
175 (26.6%)
<0.001
Coronary artery disease ( (%))
30 (27.5%)
121 (18.4%)
0.028
Congestive heart failure ( (%))
43 (39.4%)
62 (9.4%)
<0.001
History of stroke/TIA ( (%))
36 (33.0%)
82 (12.4%)
<0.001
History of smoking ( (%))
14 (12.8%)
179 (27.2%)
0.002
Disease course
Prestroke mRS (median (IQR))2
1 ()
0 ()
<0.001
NIHSS on admission (median (IQR))
14 ()
11 ()
0.042
IVT ( (%))
15 (13.8%)
308 (46.7%)
<0.001
MT ( (%))
57 (52.3%)
292 (44.3%)
0.146
MT outcomes
Full reperfusion (TICI 2b-3) ( (%))
49 (86.0%)
252 (86.3%)
1.000
sICH after MT ( (%))
19 (33.3%)
72 (27.6%)
0.420
Mortality
3 (5.3%)
23 (7.9%)
0.492
Stroke outcomes
Discharge mRS (median (IQR))3
3 ()
2 ()
0.029
Good functional outcome ( (%))3
46 (42.2%)
335 (51.4%)
0.079
Discharge NIHSS (median (IQR))4
5 ()
3 ()
0.195
Mortality ( (%))
12 (11.1%)
57 (8.7%)
0.468
1Data available in 98 DOAC (+) and 587 DOAC (-) patients. 2Data available in 109 DOAC (+) and 605 DOAC (-) patients. 3Data available in 109 DOAC (+) and 652 DOAC (-) patients. 4Data available in 97 DOAC (+) and 596 DOAC (-) patients.
