Based on the Results of PEDV Phylogenetic Analysis of the Most Recent Isolates in China, the Occurrence of Further Mutations in the Antigenic Site S1° and COE of the S Protein Which Is the Target Protein of the Vaccine

Figure 6

Protein tertiary structure modeling was performed on four representative strains of GI, GIIa, GIIb, and GIIc. (a–d) S protein 3D homology simulation modeling. Two differences were found between GI/GIIc and GIIa/b, and one difference was between GI/GIIb/GIIc and GIIa. (e–h) ORF3 protein 3D homology simulation modeling. (i–l) E protein 3D homology simulation modeling. (m–p) M protein 3D homology simulation modeling. At the end of the M protein, GIIa is longer than the other isoforms α Helix. (q–t) N protein 3D homology simulation modeling. The differential bending of the prosegment of the N protein, as revealed by inspection, is due to a homology modeling algorithm and has no practical implications.