Analyzing the Evolution and Host Adaptation of the Rabies Virus from the Perspective of Codon Usage Bias

Figure 4

Correspondence analysis and correlation analysis in different nucleotide-relevant indices of RABV. (a) The first 20 axes are applied to display the tendency of codon usage bias of RABV genomes. The plot is drawn based on the relative and cumulative inertia of the first 20 factors; the blue curve with dots represents the cumulative inertia, which is made by the result of COA. (b) Positions of the RABV genomes in the plot of the first two major axes by COA of RSCU values distributed by different countries. (c) Heatmap of correlation analysis in different nucleotide-relevant indices of RABV. Spearman test was performed to test the correlation in different nucleotide-relevant indices. ; ; and . NS, not significant. Aromo represents aromaticity of the viral gene product; GRAVY represents grand average hydropathicity score. L_sym represents the number of synonymous amino acids; L_aa represents the number of amino acids.

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