Research Article

Experimental Inoculation of Porcine Circovirus 3 (PCV-3) in Pregnant Gilts Causes PCV-3-Associated Lesions in Newborn Piglets that Persist until Weaning

Figure 3

(a) Heatmap representing the mean lesion score of periarteritis (in the mesenterium and kidney), myocarditis, pneumonia, encephalitis, and interstitial nephritis for each group and time point (F, farrowing; W, weaning). Scores have a theoretical maximum of 3; however, the maximum average score was 1.48, which was set as the maximum value in the graphic (bright red). (b) Heatmap representing the mean lesion score for each lesion (maximum value in the graphic: 2.19), for each group and time point, segregated by viral load in tissues (high means >6 log10 genome copies/mL of tissue supernatant); low means ≤ 6 log10 genome copies/mL of tissue supernatant). Negative animals from T1 and T2 groups were excluded, since they did not display lesions. (c) Heatmap representing labeling by ISH within the different tissues, for each group and time point (maximum value in the graphic: 1.44). (d) Heatmap representing labeling by ISH for each group and time point (maximum value in the graphic: 1.71), segregated by viral load in tissues.
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