A Modified Recombinant DNA-Based SARS-CoV-2 Vaccine Expressing Stabilized Uncleavable Spike Protein Elicits Humoral and Cellular Immunity against Various SARS-CoV-2 Variants of Concern

<div>Humoral response in VIU-1007 immunized mice. (a) Representation of mice immunization plan. Mice were grouped into four sets (seven mice/set) and immunized intramuscularly with either two or three doses of VIU-1007 or control plasmid (100 <i>µ</i>g/mouse) every 21 days. Blood samples were withdrawn from immunized mice 3 weeks post-second (Day 42) or -third dose (Day 63) to assess humoral responses. (b) Mean endpoint titers of SARS-CoV-2 S1 specific binding total IgG, IgG1, and IgG2 as measured by ELISA after two and three doses are shown. IgG2 : IgG1 ratios are determined from samples collected after two or three doses of VIU-1007 or control plasmid. Data are shown as mean ± SD. 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Transboundary and Emerging Diseases

fig2

Figure 2

Figure 2: A Modified Recombinant DNA-Based SARS-CoV-2 Vaccine Expressing Stabilized Uncleavable Spike Protein Elicits Humoral and Cellular Immunity against Various SARS-CoV-2 Variants of Concern 

Figure 2 | A Modified Recombinant DNA-Based SARS-CoV-2 Vaccine Expressing Stabilized Uncleavable Spike Protein Elicits Humoral and Cellular Immunity against Various SARS-CoV-2 Variants of Concern 