A Single Mutation of VP2 is Responsible for the Lethality and Antigenicity Differences between Novel Variant and Very Virulent IBDV Strains

<div>Structural comparisons of VP2 of different IBDV strains. (a) Structure of IBDV VP2. P, S, and B domains were marked with different colors. The key residue 279 was highlighted. (b) Top panel, zoomed-in view of the dashed box in (a) showing the comparison of VP2 between HLJ0504 (orange) and HLJ0504-D279N (purple) strains. Side chains of residue 279 were displayed as sticks. Bottom panel, same view of top panel showing the electrostatic surface representations of HLJ0504-D279N (left) and HLJ0504 (right) strains.</div>

Transboundary and Emerging Diseases

fig7

Figure 7

Figure 7: A Single Mutation of VP2 is Responsible for the Lethality and Antigenicity Differences between Novel Variant and Very Virulent IBDV Strains 

Figure 7 | A Single Mutation of VP2 is Responsible for the Lethality and Antigenicity Differences between Novel Variant and Very Virulent IBDV Strains 