Accuracy of Tests for Diagnosis of Animal Tuberculosis: Moving Away from the Golden Calf (and towards Bayesian Models)
Table 4
Average posterior median (APM) and 95% average posterior probability intervals (APPI) of the Se and Sp of postmortem diagnostic tests for tuberculosis in the articles reviewed.
Test
N†
Se estimates‡
APM and 95% APPI Se estimates (%)§
Sp estimates‡
APM and 95% APPI Sp estimates (%)§
Species
Culture
9
17
79.2 (64.8–88.7)
17
99.8 (98.0–100)
Tissue
8
15
79.9 (65.0–94.0)
15
99.9 (99.3–100)
Cattle, wild boar, swine, meerkat, badger
Milk and blood
1
2
15.0 (6.6–30.0)
2
97.5 (88.0–100)
Cattle
Direct PCR
10
21
80.6 (54.4–92.3)
21
97.6 (95.0–99.7)
Tissue
9
19
82.9 (69.1–92.3)
19
97.6 (95.4–99.7)
Cattle, wild boar, swine,
Milk and blood
1
2
48.5 (27.0–77.5)
2
93.0 (69.0–99.5)
Cattle
Meat inspection
5
9
53.7 (49.9–54.8)
9
99.1 (98.4–99.7)
Cattle
Histopathology
2
10
77.8 (55.2–94.6)
10
99.0 (96.8–100)
Cattle
Culture+meat inspection
1
3
74.6 (62.0–87.1)
3
98.5 (97.7–99.2)
Cattle
†Number of articles that evaluate each test. ‡Number of trials from which sensitivity and specificity estimates were extracted. §Sensitivity and specificity average posterior median and 95% average posterior probability interval of each test. Nature of the test is indicated in bold.
