Research Article

Descriptive Epidemiology and Phylodynamics of the “First Wave” of an Outbreak of Highly Pathogenic Avian Influenza (H5N1 Clade 2.3.4.4b) in British Columbia and the Yukon, Canada, April to September 2022

Table 2

Reassortant classification and genome constellations corresponding with the five genetic clusters identified among the H5N1 viruses in the British Columbia (B.C.)/Yukon outbreak.

Influenza A segment
Genetic clusterHANAMNPNSPAPB1PB2Genome constellation

Cluster 1EAEAEANAmEAEAEANAmA
Cluster 2EAEAEANAmEAEAEANAmA
Cluster 3EAEAEANAmNAmEANAmNAmB
Cluster 4EAEAEANAmEAEAEANAmA
Cluster 5EAEAEANAmEAEAEANAmA

This classification was supported by phylogenetic analyses incorporating global GISAID sequences into the phylogeny with B.C./Yukon sequences for each virus segment. EA, Eurasian lineage; NAm, North American lineage.