Pathogenesis, Transmission, and Within-Host Evolution of Bovine-Origin Influenza D Virus in Pigs

Figure 5

IDV HEF L118F mutation is close to the open receptor-binding cavity in the context of the HEF 3D structure. Left: entirety of the IDV HEF protein 3D model (reference 5e64.2) displayed as a trimer with the L118F mutation shown in red (L100F position in the context of the HEF 3D structure published by Song et al. [41]. Right: Zoom on the HEF open receptor-binding cavity (part of the HEF RBS) with the L118F (L100F) mutation displayed in red and the notable secondary structure of the HEF RBS according to Song et al. [41] shown in black.