Rapid, Multispecies Detection of SARS-CoV-2 Antibodies via a Meta-Surface Plasmon Resonance Biosensor

Figure 5

Sensitivity comparison between the PEI-GNPs MetaSPR biosensor and current methods: (a) comparison of detection sensitivity between the PEI-GNPs MetaSPR biosensor system and S-trimer-ELISA in cat serum; (b) comparison of detection sensitivity between the PEI-GNPs MetaSPR biosensor system and S-trimer-ELISA in dog serum; (c) comparison of detection sensitivity between the PEI-GNPs MetaSPR biosensor system and S-trimer-ELISA in mink serum; (d) comparison of detection sensitivity between the PEI-GNPs MetaSPR biosensor system and indirect immunofluorescence using SARS-CoV-2 antibody detection. The cat, dog, and mink SARS-CoV-2-positive sera were diluted from 1 : 100 to 1 : 16,000-fold. All of the above results are representatives of at least three independent experiments.

(a)

(b)

(c)

(d)