RBM8A Depletion Decreases the Cisplatin Resistance and Represses the Proliferation and Metastasis of Breast Cancer Cells via AKT/mTOR Pathway

Figure 1

RBM8A expression is increased in breast cancer (BC) cells and tissues. (a) QRT-PCR was performed to detect the expression of RBM8A in BC tissues and paired normal tissues. vs. normal tissues; (b) western blot was performed to measure the protein expression of RBM8A in MCF10A, MCF-7, MDA-MB-436, and MDA-MB-231 cells. , vs. MCF10A; (c) the expression of RBM8A in MCF10A, MCF-7, MDA-MB-436, and MDA-MB-231 cells was detected by qRT-PCR. , vs. MCF10A; (d and e) the expression of RBM8A in MCF-7 and MDA-MB-231 cells was assessed by qRT-PCR; (f and g) the protein level of RBM8A in MCF-7 and MDA-MB-231 cells was determined by western blotting. , vs. sh-NC. Each experiment was repeated three times.

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