Breast Cancer Patients with Brain Metastases: A Cross-Sectional Study

Table 2

Factors related to median time between diagnosis of breast cancer and occurrence of brain metastasis and median survival time after brain metastasis.

Variables		Median time for occurrence of BM (months)	Test value	Median survival time after BM (months)	Test value
Sites of metastasis at BM development	Only BM	20.2		18.3
	BM + bone	29.7	3.681^†	12	11.618^†
	BM + visceral	34.9	0.159	5.3	0.003
HER-2 status	Positive	20.4	1371.00^‡	5.3	1359.00^‡
	Negative	37.7	0.017	11.1	0.014
Breast cancer subtype	Luminal A	33.5		10.5
	Luminal B	40.6	13.702^†	7.6	7.710^†
	HER-2 overexpressing	16.8	0.003	11.6	0.052
	Triple negative	22.8		3.5
Receptor positive	Yes	39.8	1169.50^‡	7.6	1818.50^‡
	No	19.1	0.000	5.3	0.759
		Median survival time after BM (months)			Test value
Number of BM	1	12
	2	2.5			8.296^†
	Multiple	5.8			0.040
	Leptomeningeal	5.2
Treatment of BM	Radiotherapy	6.8
	Surgery	21			36.092^†
	Gamma knife	20.6			0.000

BM: brain metastasis; ^†Kruskal–Wallis test; ^‡Mann–Whitney U-test.