Research Article
Evaluation of Axillary Lymph Node Marking with Magseed® before and after Neoadjuvant Systemic Therapy in Breast Cancer Patients: MAGNET Study
| Characteristics | Overall (%) | Patients (Post-NAST) (%) | Patients (Pre-NAST) (%) |
| Number of patients (n) | 81 (100) | 37 (45.7) | 44 (54.3) | Age | Mean (SD) | 50.7 (12.7) | 50.9 (10.9) | 50.6 (14.1) | 95% CI | (48.0; 53.5) | (47.4; 54.4) | (46.4; 54.7) | Median (min; max) | 47.0 (29.0; 78.0) | 47.0 (33.0; 78.0) | 47.0 (29.0; 74.0) | P25; P75 | 41.0; 61.0 | 44.0; 56.0 | 40.0; 63.8 | Initial tumor size (cm) | Mean (SD) | 4.0 (2.9) | 3.4 (2.1) | 4.5 (3.4) | 95% CI | (3.4; 4.7) | (2.8; 4.1) | (3.5; 5.6) | Median (min; max) | 3.1 (0.0; 16.0) | 2.8 (0.0; 9.1) | 3.2 (1.5; 16.0) | P25; P75 | 2.3; 5.3 | 2.3; 3.6 | 2.6; 5.6 | Initial lymph node staging | cN1 | 81 (100) | 37 (100) | 44 (100) | Tumor pathological response (Post-NAST) | Patients | 79 | 36 | 43 | pPR | 45 (56.9) | 18 (50.0) | 27 (62.8) | pCR | 34 (43) | 18 (50.0) | 16 (37.2) | Surgical procedure on the breast | Patients | 81 | 37 | 43 | BCS | 51 (62.9) | 26 (70.3) | 25 (58.1) | MT | 30 (37) | 11 (29.7) | 18 (41.9) | Molecular classification | Patients | 81 | 37 | 44 | HER + EP+ | 27 (33.3%) | 17 (45.9%) | 10 (22.7%) | LB | 41 (50.7%) | 16 (43.3%) | 25 (56.9%) | TN | 10 (12.3%) | 4 (10.8%) | 6 (13.6%) | LA | 2 (2.5%) | 0 (0%) | 2 (4.5%) | LB/HER2+ | 1 (1.2%) | 0 (0%) | 1 (2.3%) |
|
|
Information missing for 2 cases. BCS, breast-conserving surgery; EP, estrogen and progesterone receptor; HER2 human epidermal growth factor receptor; LA, luminal A; LB, luminal B; MT, mastectomy; NAST, neoadjuvant systemic therapy; pCR, pathological complete response; pPR, pathological partial response; TN, triple negative. |