Nontherapeutic Risk Factors of Different Grouped Stage IIIC Breast Cancer Patients’ Mortality: A Study of the US Surveillance, Epidemiology, and End Results Database
Table 2
Univariate analysis related to DSS.
Variable
HR (95% CI)
value
Age at diagnosis (year)
≤40 years old
1
>40 years old
1.121 (0.824∼1.526)
0.467
Laterality
Left
1
Right
1.020 (0.848∼1.228)
0.832
Primary site
Upper-inner
1
Upper-outer
1.009 (0.677∼1.505)
0.964
Lower-inner
0.662 (0.329∼1.329)
0.246
Lower-outer
0.921 (0.543∼1.563)
0.761
Other types
0.833 (0.562∼1.236)
0.365
Histological type
Infiltrating duct carcinoma
1
Lobular carcinoma
0.994 (0.786∼1.258)
0.962
Infiltrating duct and lobularcarcinoma
1.251 (0.933∼1.678)
0.134
Other types
1.099 (0.699∼1.731)
0.681
Histological grade
Well-differentiated
1
Moderately differentiated
0.884 (0.631∼1.240)
0.477
Poorly differentiated
1.021 (0.731∼1.425)
0.904
Undifferentiated
—
—
Molecular typing
Luminal A
1
Luminal B
0.775 (0.544∼1.102)
0.156
HER-2 positive
1.206 (0.840∼1.732)
0.310
Triple negative
3.617 (2.904∼4.505)
≤0.001
ER status
Positive
1
Negative
2.661 (2.192∼3.230)
≤0.001
PR status
Positive
1
Negative
2.573 (2.137∼3.099)
≤0.001
HER-2 status
Positive
1
Negative
1.368 (1.057∼1.771)
0.017
T stage
T1
1
T2
1.068 (0.793∼1.438)
0.666
T3
1.402 (1.029∼1.910)
0.032
T4
3.011 (2.157∼4.204)
≤0.001
N3 stage
N3a
1
N3b
1.076 (0.789∼1.466)
0.644
N3c
1.975 (1.396∼2.795)
≤0.001
LNP
<14
1
≥14
1.372 (1.140∼1.652)
0.001
LNR
<0.8148
1
≥0.8148
1.682 (1.396∼2.026)
≤0.001
Among the patients who died of breast cancer included in this study, there were no patients belonging to this category. CI: confidence interval. DSS: disease-specific survival. ER: estrogen receptor. HER-2: human epidermal growth factor receptor 2. HR: hazard ratio. LNP: positive lymph nodes. LNR: lymph node ratio. PR: progesterone receptor.
