Nontherapeutic Risk Factors of Different Grouped Stage IIIC Breast Cancer Patients’ Mortality: A Study of the US Surveillance, Epidemiology, and End Results Database
Table 3
Multivariate analysis by the cox model assessing factors associated with DSS.
Variable
HR (95% CI)
value
Age at diagnosis (year)
≤40 years old
1
>40 years old
1.210 (0.881∼1.661)
0.238
Laterality
Left
1
Right
1.060 (0.878∼1.280)
0.545
Primary site
Upper-inner
1
Upper-outer
1.016 (0.678∼1.523)
0.938
Lower-inner
0.748 (0.369∼1.514)
0.420
Lower-outer
0.788 (0.460∼1.351)
0.387
Other types
0.871 (0.584∼1.299)
0.498
Histological type
Infiltrating duct carcinoma
1
Lobular carcinoma
1.115 (0.859∼1.449)
0.413
Infiltrating duct and lobularcarcinoma
1.192 (0.878∼1.618)
0.259
Other types
1.251 (0.791∼1.976)
0.338
Histological grade
Well-differentiated
1
Moderately differentiated
1.005 (0.710∼1.421)
0.979
Poorly differentiated
1.194 (0.832∼1.71)
0.336
Undifferentiated
—
—
Molecular typing
Luminal A
1
Luminal B
0.588 (0.408∼0.848)
0.004
HER-2 positive
0.168 (0.079∼0.359)
≤0.001
Triple negative
0.491 (0.243∼0.991)
0.047
ER status
Positive
1
Negative
3.632 (1.939∼6.804)
≤0.001
PR status
Positive
1
Negative
2.276 (1.751∼2.960)
≤0.001
HER-2 status
Positive
1
Negative
1
—
T stage
T1
1
T2
1.112 (0.823∼1.503)
0.489
T3
1.473 (1.077∼2.013)
0.015
T4
2.950 (2.093∼4.158)
≤0.001
N3 stage
N3a
1
N3b
0.967 (0.693∼1.349)
0.844
N3c
1.419 (0.982∼2.051)
0.063
LNP
<14
1
≥14
1.350 (1.097∼1.662)
0.005
LNR
<0.8148
1
≥0.8148
1.495 (1.221∼1.831)
≤0.001
Among the patients who died of breast cancer included in this study, there were no patients belonging to this category. CI: confidence interval. DSS: disease-specific survival. ER: estrogen receptor. HER-2: human epidermal growth factor receptor 2. HR: hazard ratio. LNP: positive lymph nodes. LNR: lymph node ratio. PR: progesterone receptor.
