Evaluating DNA Methylation in Random Fine Needle Aspirates from the Breast to Inform Cancer Risk

Table 2

Comparison of CMI from 11 incidental tissue lesions to CMI from random fine needle aspirates (rFNAs) collected from the same region or quadrant.

Histology	Size (cm)	Location	CMI of tissue lesions	CMI rFNA from same area/quadrant as lesions
ALH	0.3	Adjacent tissue	4.8	11.8
DCIS	1.0	Adjacent tissue	340.6	0.3
DCIS	2.0	Adjacent tissue	129.0	4.4
DCIS	0.4	Adjacent tissue	13.6	12.6
ALH	0.2	Ipsilateral unaffected	35.5	0.7
DCIS	0.4	Adjacent tissue	44.1	48.7
ALH	0.3	Adjacent tissue	38.0	10.0
DCIS	0.5	Adjacent tissue	14.3	0.0
DCIS	0.3	Ipsilateral unaffected	21.0	0.4
DCIS	2.0	Adjacent tissue	73.4	1.4
DCIS	1.0	Adjacent tissue	56.2	0.0

ALH, atypical lobular hyperplasia; CMI, cumulative methylation index; DCIS, ductal carcinoma in situ; rFNA, random fine needle aspiration. When there was > one lesion (i.e., DCIS/ADH), samples were categorized based on the more advanced lesion.