Candidate Oligo Therapeutic Target, miR-330-3p, Induces Tamoxifen Resistance in Estrogen Receptor-Positive Breast Cancer Cells via HDAC4

Figure 4

Gene ontology and pathway analysis of miR-330-3p. The potential mechanism involved in miR-330-3p induced tamoxifen resistance as predicted after analyzing the roles of miR-330-3p targeted substrates. (a) miR-330-3p participates in DNA-template transcription, cell adhesion, and nervous system development biological processes. (b) miR-330-3p possesses the ability to regulate metal ion binding, zinc ion binding, and transcription factor activity. (c) The downstream products are mainly located on cell junction, bicellular tight junction, intracellular ribonucleoprotein complex, nuclear pore, and PcG protein complex. (d) The targeted genes were enriched in insulin/neurotrophin/estrogen/ErbB/GnRH signaling pathways and ubiquitin-mediated proteolysis.

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