Multi-MicroRNA Analysis Can Improve the Diagnostic Performance of Mammography in Determining Breast Cancer Risk

Figure 2

Confirmation of the performance of miRNA biomarkers and algorithms in breast cancer samples in each BI-RADS category. (a) Confirmation of BI-RADS category distribution in breast cancer samples based on the four miRNAs. The expression levels (dCt) of each of the four miRNAs were compared by BI-RADS category. (b) Confirmation of BI-RADS category distribution for the combination of four miRNAs in verification data based on SVM and GLM methodology. The combination of four miRNAs in validation data based on SVM and GLM methodologies was divided into BI-RADS categories and compared based on a high-risk breast cancer cutoff value of 0.523 using verification data based on SVM and GLM methodology (negative controls are samples corresponding to healthy controls and benign breast disease BI-RADS categories 1 and 2).

(a)

(b)