Review Article

Comparison of Traditional and Advanced Resistance Training Paradigms on Muscle Hypertrophy in Trained Individuals: A Systematic Review and Meta-Analysis

Table 1

General description of the studies.

StudyADV investigated and duration and frequency of the programMuscle hypertrophy assessmentMain results for TRADMain results for ADVDifferences between protocols

Amirthalingam 2017GVT. 6 weeks of training performed 3 days per week.Lean mass through DEXA and MT through B-mode ultrasonography↑3.1, ↑4.2, and ↑7.8% in total, trunk, and arm lean mass, respectively. No significant changes in MT.↑1.9, ↑1.0, and ↑3.5% in total, trunk, and arm lean mass, respectively. No significant changes in MT.No significant differences between GVT and TRAD

Angleri 2017CP and DS. 10 weeks of training performed 2 days per week.ACSA through B-mode ultrasonography↑7.6% in ACSA↑7.5% and ↑7.8% in ACSA induced by CP and DS, respectivelyNo significant differences between CP, DS, and TRAD

Branderburg 2002EO. The training was performed 2 days per week for the first 2 weeks and then 3 days per week for the remainder of the 9-week training period.ACSA through magnetic resonance imagingNo significant changesNo significant changesNo significant differences between EO and TRAD

Enes 2021DS and RP. 8 weeks of training performed 2 days per week.MT through B-mode ultrasonography↑14.2 and ↑6.5% in the proximal thigh and middle thigh MT, respectively. No significant changes in distal thigh MT.↑11.6 and ↑7.7% in the proximal thigh and middle thigh MT, respectively, for DS. ↑8.8 and ↑5.1% in the proximal thigh and middle thigh MT for RP. No significant changes in distal MT for both groups.No significant differences between DS, RP, and TRAD

Fisher 2014PE. 12 weeks of training performed 2 days per week.Lean mass through air displacement plethysmographyNo significant changesNo significant changesNo significant differences between PE and TRAD

Fisher 2016 ASS and EO. 10 weeks of training performed 2 days per week.Lean mass through air displacement plethysmographyNo significant changesNo significant changesNo significant differences between SS, EO, and TRAD

Fisher 2016 BDS and HDS. 12 weeks of training performed 2 days per week.Lean mass through air displacement plethysmographyNo significant changesNo significant changesNo significant differences between DS, HDS, and TRAD

Hackett 2018GVT. 12 weeks of training performed 3 days per week.Lean mass through DEXANo significant changesNo significant changesNo significant differences between GVT and TRAD

Prestes 2019RP. 6 weeks of training performed 4 days per week.MT through B-mode ultrasonographyNo significant changes↑11% in thigh MT↑ in thigh MT was greater for RP

Walker 2016EO. 10 weeks of training performed 2 days per week.MT through B-mode ultrasonography and lean mass through DEXA↑11 and ↑16% in vastus lateralis and medialis MT, respectively. No significant changes in lean mass.↑13 and ↑11% in vastus lateralis and medialis MT, respectively. No significant changes in lean mass.No significant differences between EO and TRAD

The table shows resistance training programs investigated, muscle hypertrophy assessments, and main results. GVT: German volume training; MT: muscle thickness; DEXA: dual-energy X-ray absorptiometry; CP: crescent pyramid; DS: drop-set; ACSA: anatomical cross-sectional area; EO: eccentric overload; RP: rest-pause; PE: pre-exhaustion; SS: super slow; HDS: heavy DS;  = data not used in calculation of standardized mean difference due to incomplete report; ↑ = increase.