Activation of β-Adrenoceptors by Dobutamine May Induce a Higher Expression of Peroxisome Proliferator-Activated Receptors δ (PPARδ) in Neonatal Rat Cardiomyocytes
Figure 4
Effects of PPARδ-targeted siRNA on dobutamine-induced actions in neonatal rat cardiomyocytes. The neonatal rat cardiomyocytes transfected with siRNA-targeted to PPARδ or siRNA-scramble (siRNA-control) were incubated with 1 μmol/L dobutamine. All cells were then harvested to measure PPARδ expression (a) or cTnI phosphorylation (b) using Western blotting analysis. All values are expressed as mean ± SEM ( per group). * as compared with the vehicle-treated control and # as compared with the dobutamine-treated cells transfected with the scramble siRNA (siRNA-control).
