Study of the Activity of 3-benzyl-5-(4-chloro-arylazo)-4-thioxo-imidazolidin-2-one against Schistosomiasis Mansoni in Mice
Figure 2
Photomicrographs of granuloma stage in the livers of mice infected by S. mansoni. (a) Infected control exhibiting exudative-productive stage granulomas (arrows) with a mature, viable egg in the center of the fibrocellular granulomas. (b) LPSF-PT05-PEG (3 mg/kg per day); micrographs show well-circumscribed small fibrocellular granulomas and marked ovum degeneration (asterisks). (c) LPSF-PT05-PEG (10 mg/kg per day); productive (arrow) and involutional (asterisk) granulomas stage. (d) LPSF-PT05-PEG (30 mg/kg per day). (e) LPSF-PT05-PEG (100 mg/kg per day) involutional stage granulomas (asterisks). H&E, micrographs are at 100x magnification.
