CD4+CD25highCD127low Regulatory T Cells in Peripheral Blood Are Not an Independent Factor for Chronic Graft-versus-Host Disease after Allogeneic Stem Cell Transplantation
Table 3
Univariate analysis for chronic graft versus host disease (cGVHD).
No cGVHD ()
Limited or extensive cGVHD ()
value
Median (range)
Median (range)
Patient age (year)
44.5 (19–63)
46.5 (19–67)
0.17
Time after transplantation (day)
505 (150–2430)
577.5 (164–3606)
0.41
Lymphocytes × 106/l
1383 (99.5–3415.8)
1299 (118–3423.8)
0.68
CD3+CD4+ % of lymphocytes
33.2 (6.3–62.9)
22.6 (3.4–62.9)
0.02
CD3+CD4+ × 106/l
249.5 (34–1124.6)
312.4 (32.9–1094)
0.07
CD4+CD25highCD127low % of lymphocytes
1.7 (0.08–4.2)
2.2 (0.5–9.5)
0.026
CD4+CD25highCD127low × 106/l
17.06 (1.6–79.4)
24.5 (2.96–114.7)
0.033
Number
Number
Gender (male/female)
24/14
26/20
0.65
Conditioning (myeloablative/RIC)
22/16
24/22
0.66
Donor type (sibling/unrelated)
14/24
24/22
0.19
In vivo T-cell depletion with ATG (no/yes)
10/28
20/26
0.11
HLA match (match/mismatch)
10/28
14/32
0.8
CMV serostatus (negative in both/other)
8/30
14/32
0.46
Gender match (match/mismatch)
22/16
23/23
0.51
Blood group match (match/mismatch)
20/18
28/18
0.5
CD: cluster of differentiation, RIC: reduced intensity conditioning, ATG: antithymocyte globulin, HLA: human leukocyte antigen, and CMV: cytomegalovirus.
