Phosphodiesterase Inhibitors Suppress Lactobacillus casei Cell-Wall-Induced NF-𝜿B and MAPK Activations and Cell Proliferation through Protein Kinase A—or Exchange Protein Activated by cAMP-Dependent Signal Pathway

Figure 6

Change in cell proliferation after treatment with LCWE (10 μg/mL), a combination of IBMX (1 μM) and LCWE (10 μg/mL), or a combination of IBMX (1 μM), LCWE (10 μg/mL), and H89 (5 μM) (a) in NIH3T3 mouse fibroblast cells. Change in cell proliferation after treatment with LCWE (10 μg/mL), a combination of 8-Br-cAMP (1 mM) and LCWE (10 μg/mL), or a combination of 8-CPT-cAMP (5 μM) and LCWE (10 μg/mL) (b) in NIH3T3 mouse fibroblast cells. Each column represents the mean ± SEM. *𝑃<0.05  versus untreated controls. ^#𝑃<0.05  versus LCWE treatment group.

(a)

(b)