Prostatic Relaxation Induced by Loperamide Is Reduced in Spontaneously Hypertensive Rats

Table 1

The inhibitory effect of cyprodime or naloxonazine on the relaxation of loperamide (10 μmol/L) in isolated SHR prostates contracted with 1 μmol/L phenylephrine (PE) or 50 mmol/L KCl. Data represent mean ± SEM of eight animals.

	PE (%)	KCl (%)
Loperamide (10 μmol/L)
+ Vehicle	72.91 ± 1.05	61.45 ± 2.43
+ Cyprodime
0.1 μmol/L	81.23 ± 0.71***	78.92 ± 0.76**
1.0 μmol/L	92.60 ± 1.30***	86.68 ± 1.98***
+ Naloxonazine
0.1 μmol/L	70.62 ± 1.02	60.77 ± 1.00
1.0 μmol/L	70.19 ± 2.17	63.79 ± 1.92

** 𝑃<0.01 and ***𝑃<0.001 compared with vehicle-treated control.