Prostatic Relaxation Induced by Loperamide Is Reduced in Spontaneously Hypertensive Rats

Table 2

The effects of inhibitors for signals on the relaxation induced by loperamide (10 μmol/L) in SHR isolated prostates contracted with 1 μmol/L phenylephrine (PE) or 50 mmol/L KCl. Data represent mean ± SEM of eight animals.

	PE (%)	KCl (%)
Loperamide (10 μmol/L)
+ Vehicle	73.53 ± 1.06	63.17 ± 2.55
+ IBMX (10 μmol/L)	62.16 ± 1.62**	51.20 ± 1.18*
+ H-89 (1 μmol/L)	86.42 ± 1.59***	81.66 ± 1.62**
+ Glibenclamide (1 μmol/L)	93.21 ± 0.62***	85.02 ± 0.68***

* 𝑃<0.05, **𝑃<0.01 and ***𝑃<0.001 compared with vehicle-treated control, respectively.