Effect of Creatine Monohydrate Supplementation on Various Hematological and Serum Biochemical Parameters of Male Albino Mice following Neonatal Hypoxia-Ischemia Encephalopathy

Table 2

Comparison of various hematological and serum biochemical parameters between 2% creatine monohydrate treated and untreated (control) male albino mice for 12 weeks following hypoxia and ischemia: data is expressed as mean ± standard deviation.

Parameters	Creatine monohydrate treated group		Untreated control group		𝑃 value
	Mean ± SD	Range	Mean ± SD	Range
Hematological profile
WBC (×10^9/L)	5.91 ± 2.85	3.4–10.7	9.170 ± 6.518	5.15–20.5	0.347 ns
RBC (×10^12/L)	6.79 ± 2.74	4.59–10.86	6.76 ± 2.60	3.95–9.61	0.985 ns
PCV%	27.83 ± 7.41	19.2–39.5	25.03 ± 5.42	20–33	0.492 ns
Glucose (mg/dL)	169.5 ± 78.8	101–280	115.8 ± 40.2	60–162	0.188 ns
MCV (fp)	47.1 ± 22.8	19.8–80.4	40.3 ± 11.9	26–50.6	0.544 ns
Serum biochemical profile
Total protein (g/dL)	3.2 ± 0.1	3.1–3.3	34.7 ± 27.3	17.4–66.1	0.184 ns
Triglycerides (mg/dL)	427 ± 314	65–616	305.3 ± 68.0	228–356	0.579 ns
Cholesterol (mg/dL)	358.4 ± 32.4	318–394	753.3 ± 33.1	722–788	𝑃>0.001^∗∗∗
HDL (mg/dL)	20.67 ± 4.04	17–25	35.0 ± 20.0	18–57	0.347 ns
LDL (mg/dL)	240.3 ± 72.5	173–317	656.7 ± 21.9	632–674	0.011*
ALAT (𝜇/L)	72.33 ± 6.81	67–80	191.7 ± 10.4	180–200	𝑃>0.001^∗∗∗
ASAT (u/L)	231.7 ± 10.4	22–240	161.7 ± 22.5	140–185	0.639 ns

𝑃<0.05 = non-significant (ns), ^∗𝑃>0.05 = Least significant, ^∗∗∗𝑃>0.001 = highly significant.