Design, Development, and Optimization of Polymeric Based-Colonic Drug Delivery System of Naproxen

Table 1

Composition of naproxen sodium core, press-coated tablets, and enteric-coated tablets.

Ingredients	NF1	NF2	NF3	NF4	NF5	NF6	NF7	NF8	NF9
Drug	+	+	+	+	+	+	+	+	+
Lactose	+	+	+	+	+	+	+	+	+
Starch	+	+	+	+	+	+	+	+	+
Magnesium Stearate	+	+	+	+	+	+	+	+	+
HPC	−	+	+	+	+	−	−	−	−
RSPO : RLPO	−	−	−	−	−	+	+	+	+
*ED S-100; 2.5% w/v	−	−	+	−	−	−	+	−	−
*ED S-100; 5.0% w/v	−	−	−	+	−	−	−	+	−
*ED S-100; 7.5% w/v	−	−	−	−	+	−	−	−	+

+Sign indicates presence of ingredient.
−Sign indicates absence of ingredient.
∗Eudragit S-100.