Phytochemical and Antibacterial Investigations of the Extracts and Fractions from the Stem Bark of Hymenaea stigonocarpa Mart. ex Hayne and Effect on Ultrastructure of Staphylococcus aureus Induced by Hydroalcoholic Extract

Table 2

Minimal inhibitory concentrations of the extracts and fractions from Hymenaea stigonocarpa against Gram-positive  cocci.

Gram-positive  cocci	Origin	Minimal inhibitory concentrations (𝜇g/mL)									Resistance phenotype
		CE	EAE	EE	AE	HE	AF	EAF	OXA	TEI
Staphylococcus aureus ATCC 25293	ATCC	512	512	256	512	128	128	128	0.12	—	Control strain
Staphylococcus aureus ATCC 33591	ATCC	1024	512	256	512	256	256	512	64	—	Control strain
Staphylococcus aureus LFBM 05	Hemoculture	1024	512	256	512	256	125	512	32	—	AMP, AZI, CFO, PEN
Staphylococcus aureus LFBM 11	ND	512	512	128	128	128	128	256	1.0	—	PEN
Staphylococcus aureus LFBM 13	Vaginal secretion	512	512	512	512	128	64	512	1.0	—	PEN
Staphylococcus aureus LFBM 15	Sputum	512	512	128	512	64	64	256	0.12	—	PEN, GET, ERI, CLI
Staphylococcus aureus LFBM 16	Hemoculture	512	512	256	512	256	125	256	0.12	—	AMP, AZI, CFO, PEN
Staphylococcus aureus LFBM 25	Hemoculture	512	512	256	512	256	256	256	256	—	PEN, GET, ERI, RIF, CLI
Staphylococcus aureus LFBM 26	Hemoculture	512	512	256	512	64	64	512	256	—	AMC, AMP, CFO, CIP
Staphylococcus aureus LFBM 28	Tracheal secretion	1024	512	256	512	256	128	512	16	—	AMC, CIP, CFO, GET
Staphylococcus aureus LFBM 29	Hemoculture	1024	512	256	512	256	256	512	8.0	—	AMC, AMP, CFO, PEN
Staphylococcus aureus LFBM 30	Tracheal secretion	1024	512	256	512	256	256	512	16	—	AMC, AMP, CFO, CIP
Enterococcus faecalis LFBM 02	Hemoculture	1024	512	256	256	256	256	512	—	8.0	CIP, PEN, ERI, IMI, TET
Enterococcus faecalis LFBM 07	Hemoculture	1024	512	256	512	512	256	512	—	8.0	CIP, PEN, ERI, IMI, TET
Enterococcus faecalis LFBM 08	Urine	1024	512	256	512	256	256	512	—	0.25	None antibiotic
Enterococcus faecalis LFBM 18	Hemoculture	1024	512	256	512	256	256	512	—	4.0	CIP, PEN, ERI, IMI, TET

ATCC: American Type Culture Collection; CE: cyclohexanic extract; EAE: ethyl acetate extract; EE: ethanolic extract; AE: aqueous extract; HE: hydroalcoholic extract; AF: aqueous fraction; EAF: ethyl acetate fraction; OXA: oxacillin; AMP: ampicillin; AZI: azithromycin; CFO: cefoxitin; CIP: ciprofloxacin; GET: gentamicin; PEN: penicillin; CLI: clindamycin; ERI: erythromycin; IMI: imipenem; RIF: rifampin; TET: tetracycline; LFBM: Laboratório de Fisiologia e Bioquímica de Microorganismos; ND: not determined.