Expression Profiling Using a cDNA Array and Immunohistochemistry for the Extracellular Matrix Genes FN-1, ITGA-3, ITGB-5, MMP-2, and MMP-9 in Colorectal Carcinoma Progression and Dissemination

Table 2

Distribution of expression levels of FN-1, ITGA-3, ITGB-5, MMP-2, and MMP-9 ECM genes, with significance levels of 𝑃<0.05, fold change >2.0, and clinicopathological variables associated with genetic tracing by RT-PCR.

Gene	𝑃 value	Fold change	Clinicopathological parameter	Comparison
FN-1	0.022	−3.07	Age (years)	<60 × ≥60
ITGA-3	0.016	2.58	TNM	TNM III × TNM I
ITGB-5	0.04	−2.11	Degree of cell differentiation	GII × GI
	0.029	1.33	TNM	TNM III × TNM I
MMP-2	0.015	2.17	Histological type	Mucinous × tubular
	0.04	−1.2	Peritumoral lymphocyte infiltration	With × without
	0.039	−2.11	Age	>60 × ≤60
MMP-9	0.014	1.13	Histological type	Villous × tubular