Synthesis, Characterization, and Anticancer Activity of New Quinazoline Derivatives against MCF-7 Cells

Figure 12

Cell cycle analysis. (a) Effect of (1) and (2) on cell cycle arrest. After incubation with DMSO or different concentrations of (1) and (2) for 24 h, MCF-7 cells were stained with BrdU and phosphohistone H3 and subjected to the Cellomics ArrayScan HCS reader for cell cycle analysis. (b) Representative bar charts indicating that treatment of both compounds markedly decreased BrdU and phosphohistone H3 fluorescence intensities in treated MCF-7 cells. Data were expressed as the mean ± SD of fluorescence intensity readings for three independent experiments.

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