Research Article
Synthesis, Characterization, and Anticancer Activity of New Quinazoline Derivatives against MCF-7 Cells
Figure 14
Effects of the Quinazoline Schiff bases on nuclear morphology, membrane permeability, mitochondrial membrane potential (MMP), and cytochrome c release. (a) Representative images of MCF-7 cells treated with medium alone and at 4 × 10−6, 8 × 10−6, and 16 × 10−6 mol/L concentrations of compounds and stained with Hoechst 33342 for nuclear, cytochrome c, membrane permeability, and MMP dyes. Both compound induced a noteworthy elevation in membrane permeability and cytochrome c release and a marked reduction in mitochondrial membrane potential (magnification: 200x). (b) Representative bar charts indicating dose-dependent increased cell permeability reduced MMP and increased cytochrome c release in treated MCF-7 cells.
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