A Chinese Herbal Medicine, Jia-Wei-Xiao-Yao-San, Prevents Dimethylnitrosamine-Induced Hepatic Fibrosis in Rats
Figure 1
Histological examination performed by conducting Masson trichrome staining, 100x of JWXYS-treated and untreated rat liver. (a) vehicle, normal saline; control, normal liver; (b) DMN alone with marked widening, inflammation, and fibrotic portal tracts with bridging fibrosis. Nodular transformation was apparent. (c) DMN + 200 mg/kg of silymarin with moderate widening and fibrotic portal tracts with occasional bridging fibrosis; (d) DMN + 100 mg/kg of JWXYS with moderate widening and fibrotic portal tracts with bridging fibrosis and mild inflammatory cell infiltration; (e) DMN + 300 mg/kg of JWXYS with focal mild fibrotic change of the portal tracts and bridging fibrosis; (f) DMN + 1000 mg/kg of JWXYS with mild to moderate fibrotic portal tracts with bridging fibrosis.
