An Improved Pearson’s Correlation Proximity-Based Hierarchical Clustering for Mining Biological Association between Genes

Algorithm 2

Seed Augment algorithm.

Begin

Input: Similarity gene expression patterns obtained from Algorithm 1, GL-PCPHC (𝑃, 𝑄, 𝐶_𝑃, 𝑒_max and ℎ_min)

//Expression Matrix Column Expansion

For 𝐶_𝑖∈ 𝐶- 𝑃

 do

  For 𝑂_𝑖 in 𝑂(𝑃, 𝑄)

 Do

   𝑂_𝑖 = COLEXPANSION (𝑒_max and ℎ_min)

     End for

End for

//Expression Matrix Row Expansion

For 𝑅_𝑖∈ 𝑅- 𝑄

 do

For 𝑂_𝑖 in 𝑂(𝑃, 𝑄)

   𝑂_𝑖 = ROWEXPANSION (𝑒_max and ℎ_min)

  End for

End for

Obtain distance between two genes from (4)

End