Syntheses of Isoxazoline-Carbocyclic Nucleosides and Their Antiviral Evaluation: A Standard Protocol
Table 4
Cytotoxicity and antiviral activity of compounds 14a,b and 16a,b in Vero cell cultures.
Compound
MCCa (μg/mL)
MICb (μg/mL)
PiV
RV
SV
CV
PTV
14aA
80
>16
>16
>16
>16
>16
14aB
400
>80
>80
>80
>80
>80
14aC
80
>16
>16
>16
>16
>16
14aD
400
>80
>80
>80
>80
>80
14bA
≥400
>80
>80
>80
>80
>80
14bB
400
>80
>80
>80
>80
>80
14bC
80
>16
>16
>16
>16
>16
14bD
400
>80
>80
>80
>80
>80
16aU
400
>80
>80
>80
>80
>80
16aT
400
>80
>80
>80
>80
>80
16bU
400
>80
>80
>80
>80
>80
16bT
400
>80
>80
>80
>80
>80
Brivudine
>400
>400
>400
>400
>400
>400
Ribavirin
>400
48
48
240
48
48
(S)-DHPA
>400
48
240
>400
>400
>400
Minimum cytotoxic concentration, required to cause a microscopically detectable alteration of normal cell morphology.
bMinimum inhibitory concentration required to reduce virus-induced cytopathogenicity by 50%.
