Inhibitory Effect of Cinobufagin on L-Type C Currents, Contractility, and C Homeostasis of Isolated Adult Rat Ventricular Myocytes

Figure 3

CBG dose-dependently inhibits 𝐼_Ca-L. (a) Time course of 𝐼_Ca-L recorded under control conditions, during exposure to 10⁻¹², 10⁻¹¹, 10⁻¹⁰, 10⁻⁹, and 10⁻⁸ M CBG and 0.1 mM Ver. (b) Traces of 𝐼_Ca-L evoked in the absence and presence of CBG derivatives. (c) Dose-response curve demonstrating the inhibitory effects of CBG on 𝐼_Ca-L. Data are presented as means ± S.E.M. (𝑛=5–7 cells).

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(b)

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