A Schiff Base-Derived Copper (II) Complex Is a Potent Inducer of Apoptosis in Colon Cancer Cells by Activating the Intrinsic Pathway
Figure 7
(a) Representative images of HT-29 cells treated with medium alone and 2 μg/mL of Cu(BrHAP)2 and stained with Hoechst 33342 for nuclear, cytochrome c, membrane permeability, and mitochondrial membrane potential dyes. Cu(BrHAP)2 induced a noteworthy elevation in membrane permeability and cytochrome release and a marked reduction in mitochondrial membrane potential (magnification: 200x). (b) Representative bar charts indicating dose-dependent increased cell permeability reduced MMP and increased cytochrome release in treated HT-29 cells.
