Isoprenaline: A Potential Contributor in Sick Sinus Syndrome—Insights from a Mathematical Model of the Rabbit Sinoatrial Node

Figure 3

Effect of Iso on the SAN pacemaking rate. Simulated voltage from (a) central cell models and ((b) and (c)) peripheral cell models. Action potentials are shown under control conditions and in the presence 0.1 μM/L Iso, 0.01 μM/L Ach, and the DelF1617 mutant channel.

(a)

(b)

(c)