Salicylanilide Diethyl Phosphates as Potential Inhibitors of Some Mycobacterial Enzymes

Table 2

Mycobacterial enzyme activity inhibition results.

Comp. code	R^1	R^2	% inhibition at 50 M against L-MtAlaDH	L-MtAlaDH; IC50 (M)	% inhibition at 50 M against MtLAT	% inhibition at 50 M against MtCM	% inhibition at 50 M against MtPS
1a	4-Br	3-F	69.94	39.75	7.80	40.50	7.47
1b	4-Br	3-Cl	59.46	41.12	18.73	43.50	3.89
1c	4-Br	4-Cl	39.35	50	29.10	48.31	13.25
1d	4-Br	3,4-di-Cl	59.02	31.92	30.27	41.30	20.54
1e	4-Br	3-CF3	42.08	50	40.20	53.20	17.76
1f	4-Br	4-CF3	69.28	34.73	26.15	52.09	11.33
1g	4-Br	3-Br	22.62	50	12.42	46.07	18.76
1h	4-Br	4-Br	34.35	50	18.25	38.19	18.33
1i	4-Br	4-F	54.58	15.58	2.90	46.67	5.41
1j	4-Cl	3-Cl	12.30	50	29.30	54.56	3.64
1k	4-Cl	4-Cl	18.73	50	38.00	43.78	14.74
1l	4-Cl	3-F	61.87	23.11	8.06	50.75	17.93
1m	4-Cl	4-F	57.70	42.26	20.12	49.33	7.76
1n	4-Cl	4-Br	70.64	29.17	17.29	50.19	6.57
1o	4-Cl	3,4-di-Cl	44.46	50	18.24	60.96	23.01
1p	4-Cl	3-Br	54.64	36.11	19.13	37.41	20.59
1q	4-Cl	3-CF3	73.88	36.32	19.05	50.02	11.53
1r	4-Cl	4-CF3	47.28	50	23.18	50.05	26.25
1s	5-Cl	3-Cl	73.94	4.96	53.64	60.12	11.18
1t	5-Cl	3-Br	41.51	50	12.86	57.58	5.04
1u	5-Cl	3-F	59.85	39.20	23.42	52.36	22.22
1v	5-Cl	4-F	69.07	34.47	37.29	52.05	17.28
1w	5-Cl	4-Br	14.97	>50	40.28	52.84	14.51
1x	5-Cl	4-Cl	58.62	46.51	20.18	53.79	11.17
1y	5-Cl	3,4-di-Cl	26.30	50	28.17	56.65	12.38
1z	5-Cl	3-CF3	58.32	17.82	10.01	43.49	4.51
1zz	5-Cl	4-CF3	64.82	37.49	19.83	54.09	8.26

The best results for each enzyme are shown in bold.