Novel Glycolipids Synthesized Using Plant Essential Oils and Their Application in Quorum Sensing Inhibition and as Antibiofilm Agents

Table 1

Tabulated data showing quorum sensing inhibitory (QSI) activity of essential oils used in this study, alone and in combination with 10 mg/mL of OASL. Also QSI activity of all synthesized EOSLs.

Plant essential oil (common name)	Plant essential oil (scientific name)	Main component	Anti-QSI activity of essential oil alone (20% oil) against CV026 (inhibition zone size in mm)	Anti-QSI activity of EO + OASL against CV026 (inhibition zone size in mm)^a	Anti-QSI activity of EOSL against CV026 (inhibition zone size in mm)^b
Lemongrass oil	Cymbopogon citratus	Citral	15	28	25
Peppermint oil	Mentha piperita	Menthol	—	16	13
Cinnamon oil	Cinnamomum verum	Cinnamaldehyde	15 (10% EO)	20 (10% EO + OASL at 10 mg/mL)	Growth inhibition at 10 mg/mL EOSL.
Rosemary oil	Rosmarinus officinalis	(+) Alpha pinene	—	—	13
Basil oil	Ocimum basilicum	L-Linalool	—	11	30
Bergamot oil	Citrus bergamia	L-Linalool	—	—	17
Eucalyptus oil	Eucalyptus sp.	1,8-Cineole	—	—	23
Orange oil	Citrus sinensis	Limonene	—	—	13
Citronella oil	Cymbopogon nardus	Citronellal	—	—	12
Tea tree oil	Melaleuca alternifolia	Alpha terpineol	—	—	26
Ylang ylang oil	Cananga odorata	L-Linalool	—	12	33
Frankincense oil	Boswellia carteri	(+) Alpha pinene	—	—	17

a1 mL reaction mixture contained 20% EO and OASL at a concentration of 10 mg/mL. Also OASL alone used at a concentration of 10 mg/mL had no QSI activity.
^bEOSL concentration used 20 mg/mL.