Antimicrobial Resistance Trends among Community-Acquired Respiratory Tract Pathogens in Greece, 2009–2012

Table 3

Comparison of antibiotic resistance rates in S. pneumonia isolates over the periods 2009-2010 and 2011-2012.

	2009-2010							2011-2012
Antibiotic	MIC50	MIC90	Range	𝑆%	𝐼%	𝑅%	MIC50	MIC90	Range	𝑆%	𝐼%	𝑅%	𝑃 value
Penicillin	0.023	2	<0.016–4	58.1	24.3	17.6	0.023	0.75	<0.016–4	63.2	30.4	6.4	0.09
Cefuroxime	0.023	3	<0.016–6	72.1	1.4	26.5	0.023	2	<0.016–4	80.8	2.4	16.8	0.10
Cefotaxime	0.023	1	<0.016–2	93.4	5.9	0.7	0.023	0.55	<0.016–1.5	98.4	1.6	—	0.10
Ceftriaxone	0.023	1	<0.016–1.5	94.1	5.9	—	0.023	0.5	<0.016–1	99.2	0.8	—	0.03
Cefepime	0.064	2	0.0023–3	81.6	14.7	3.7	0.125	2	0.016–6	84	7.2	8.8	0.15
Imipenem	0.016	0.19	0.003–0.75	88.2	10.3	1.4	0.047	0.125	0.006–0.5	94.4	5.6	—	0.10
Meropenem	0.012	0.38	0.004–1	88.2	8.8	2.9	0.032	0.125	0.006–1	96	2.4	1.6	0.14
Erythromycin	0.094	≥256	0.047–≥256	70.6	—	29.4	0.064	≥256	0.016–≥256	71.2	—	28.8	1.00
Clarithromycin	0.094	≥256	0.016–≥256	70.6	—	29.4	0.047	≥256	0.016–≥256	71.2	—	28.8	1.00
Clindamycin	0.125	≥256	0.032–≥256	89.7	—	10.3	0.064	≥256	0.023–≥256	82.4	1.6	16	0.10
Roxithromycin	0.125	≥256	0.047–≥256	70.6	—	29.4	0.094	≥256	0.016–≥256	71.2	—	28.8	1.00
Azithromycin	0.5	≥256	0.125–≥256	70.6	—	29.4	0.19	≥256	0.023–≥256	71.2	—	28.8	1.00
Ciprofloxacin	0.75	1.5	0.385–≥32	99.3	—	0.7	0.75	1	0.25–≥32	99.2	—	0.8	1.00
Levofloxacin	0.75	1	0.19–16	99.3	—	0.7	0.75	1	0.19–≥32	99.2	—	0.8	1.00
Moxifloxacin	0.125	0.19	0.032–1.5	99.3	0.7%	—	0.125	0.19	0.047–3	99.2	—	0.8	0.16
Chloramphenicol	2	2	0.38–12	99.3	—	0.7	2	3	0.75–32	96.8	—	3.2	0.19
Tetracycline	0.125	16	0.016–48	74.3	1.4	24.3	0.25	32	0.064–64	79.2	—	20.8	0.10
Cotrimoxazole	0.19	1.5	0.016–≥32	77.2	14.7	8.1	0.094	1.5	0.023–≥32	83.2	9.6	7.2	0.10
Vancomycin	0.38	0.5	0.25–0.5	100	—	—	0.38	0.5	0.25–0.75	100	—	—	NA∗

∗NA: not applicable.