Tristemma hirtum and Five Other Cameroonian Edible Plants with Weak or No Antibacterial Effects Modulate the Activities of Antibiotics against Gram-Negative Multidrug-Resistant Phenotypes
Table 8
Antibiotic-resistance modulatory activity of leaves extract of Tristemma hirtum.
Antibiotics
Extract concentration
Bacteria, MIC (μg/mL) and modulating factors (in brackets)
Escherichia coli
Enterobacter aerogenes
Klebsiella pneumoniae
Providencia stuartii
Pseudomonas aeruginosa
Modulating effect (%)
AG100A
AG102
EA289
KP63
NEA16
PA01
PA124
CHL
0
256
256
128
64
128
256
128
CMI/2
128 (2)
≤2 (≥128)
16 (8)
16 (4)
16 (8)
64 (4)
8 (16)
100.00
CMI/4
128 (2)
≤2 (≥128)
16 (8)
16 (4)
16 (8)
64 (4)
8 (16)
100.00
KAN
0
8
64
64
64
64
64
128
CMI/2
≤2 (≥4)
16 (4)
≤2 (≥32)
16 (4)
16 (4)
≤2 (≥64)
64 (2)
100.00
CMI/4
≤2 (≥4)
16 (4)
≤2 (≥32)
32 (2)
32 (2)
≤2 (≥64)
64 (2)
100.00
CEF
0
64
64
64
128
256
64
128
CMI/2
8 (8)
8 (8)
8 (8)
16 (8)
32 (8)
≤2 (≥32)
128 (1)
85.71
CMI/4
128 (0.5)
32 (2)
32 (2)
32 (4)
32 (8)
≤2 (≥32)
256 (0.5)
71.42
CIP
0
16
16
8
32
32
16
64
CMI/2
8 (2)
≤0.5 (≥32)
≤0.5 (≥16)
4 (8)
16 (2)
≤0.5 (≥32)
32 (2)
100.00
CMI/4
8 (2)
4 (8)
≤0.5 (≥16)
4 (8)
16 (2)
≤0.5 (≥32)
32 (2)
100.00
TET
0
>64
64
32
64
32
>64
16
CMI/2
32 (≥2)
32 (2)
≤0.5 (≥64)
4 (16)
4 (8)
32 (≥4)
8 (2)
100.00
CMI/4
32 (≥2)
32 (2)
8 (4)
8 (8)
4 (8)
64 (≥2)
8 (2)
100.00
ERY
0
>256
128
>256
128
128
>256
128
CMI/2
128 (≥2)
8 (16)
16 (≥16)
32 (4)
64 (2)
32 (≥8)
128 (1)
85.71
CMI/4
128 (≥2)
16 (8)
32 (≥8)
32 (4)
64 (2)
64 (≥4)
256 (0.5)
85.71
CHL: chloramphenicol, KAN: kanamycin, CEF: ceftriaxone, CIP: ciprofloxacin, TET: tetracycline, and ERY: erythromycin; in brackets: modulating factor; MIC: minimal inhibitory concentration. Values in bold represent modulating factor ≥ 2.
